According to Tony Yayo, Jimmy Henchman caused the rift between 50 Cent and The Game.

"The poison in that was Jimmy Henchman. Jimmy Henchman never liked Chris Lighty. It was always jealousy.  Chris Lighty always had hate from people," Yayo said, explaining that the jealousy from folks like Henchman stemmed from how many artists -- like 50 Cent -- were with Lightly. 

Now Henchman, who 50 despised, was tight with The Game and would be his manager for a time.  So when a G-Unit era Game notoriously announced that he isn't beefing with everyone 50 is beefing with he was likely referring to Henchman.  

50 would kick Game out of G-Unit for those disloyal words.

"When you're in a group, man, it's egos," Yayo said. "Motherf*ckers is from the hood. N*ggas ain't got no money. No financial experience, nothing... It's egos."